ABSTRACT
Objective To observe the effects of Haizao Yuhu Decoction on the CXCR 4 expression of TT cell tumor-bearing mice. Methods Culture the human thyroid TT cells in vitro, and inoculate them into 30 healthy mice BALB/C. Subsequently, Haizao Yuhu Decoction was given to the tumor-bearing mice. They are grouped into three groups, including tumor-bearing group (n=10), Haizao Yuhu Decoction high dosage group (n=10) and Haizao Yuhu Decoction low dosage group (n=10) to observe the tumor growth to calculate the anti-tumor rate. After the tumor has been reaped, immunohistochemical is adopted to test the expressions of chemotactic factor receptor-CXCR 4 on protein level. RT-PCR is used to test the expressions of CXCR 4 on genetic level. Results Comparing with the tumor-bearing group, HZYHD high-dosage group has decreased the expressions of CXCR 4 on both the protein and genetic levels, which is to certain degree dependent on concentration.Conclusion Haizao Yuhu Decoction could decrease the expression of CXCR 4.
ABSTRACT
Objective To evaluate the efficacy and safety of adjuvant IFN therapy for viral hepatitis-related hepatocellular carcinoma(HCC)after treatment with surgical resection or transarterial chemoembolization(TACE).Methods Controlled trials of adjuvant treatment with IFN for patients with HCC published between 2000 and 2012 were searched electronically in MEDLINE,PubMed,Cochrane Library,and EMBASE databases.According to the heterogeneity of the studies,two different models-the fixed-effect model and the random-effect model-were applied to analyze the results. Results Ten trials were screened according to inclusion and exclusion standards.Eight randomized,controlled trials and two non-randomized,controlled trials were included.These ten trials with a total of 1 ,029 subjects were eventually involved in the meta-analysis;528 HCC patients were treated with adjuvant treatment with IFN and 501 patients with placebo.Compared to the control group,the recurrence rates of HCC in IFN group were significantly lower CR=0.66;95% CI=0.50 to 0.86;P=0.02),especially after TACE treatment according to subgroup analysis(OR=0.73;95%CI=0.52 to 1.01;P=0.06 for surgical resection;and OR=0.54;95%CI=0.33 to 0.86,P=0.01 for TACE).The death rates in the IFN group also significantly decreased according to not only total events analysis(OR=0.42;95%CI=0.32 to 0.56;P<0.01)but also subgroup analysis(OR=0.51;95%CI=0.36 to 0.72;P=0.0002 for surgical resection;and OR=0.33;95%CI=0.21 to 0.50;P<0.01 for TACE).Conclusion Adjuvant IFN therapy may significantly reduce the recurrence rates of patients with viral hepatitis-related HCC and improve the survival of patients after surgical resection or TACE.The ideal dose mostly selected is 3 MIU/mL,three times per week,which can make patients tolerate the adverse reactions of IFN better and maintain effective concentrations for a long time.
ABSTRACT
Objective To explore the influence of gender and age on hip and plantar pressure changes in the sit-to-stand transition. Methods Kinematic parameters such as changes in hip joint angle,motor velocity and speed,and also plantar pressure changes such as stress,pressure and contact area were observed as subjects of different ages and genders performed sit-to-stand transitions. Results ①Hip kinematics:The speeds of trunk movement and hip joint angle change in men and women were significantly different.Their average speed in rising was also significantly different.The young and middle-aged people rose faster with faster hip joint angle changes than the elderly.Their total rising time was therefore significantly shorter as well.()Plantar pressure kinematics:The men's plantar pressures were significantly higher than those of the women throughout the rising process.The plantar pressure of the young and middle-aged subjects was also significantly higher than that of the elderly.At the last stage of sit-to-stand transfer process the ground contact area of the women's was significantly larger,on average,than that of the men,and the elderly had significantly larger contact areas than young or middle-aged people. Conclusion During sit-to-stand transfers,men and young people move faster than women or the elderly.Women and older people tend to have larger foot-ground contact areas than men and younger persons.Different rehabilitation measures are required for different ages,genders and diseases.